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New Drug Delays Male Orgasms, Study Finds


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New drug delays male orgasms, study finds

By Maggie Fox, Health and Science Correspondent

Mon May 23, 4:42 PM ET

WASHINGTON (Reuters) - The first drug formulated to treat premature ejaculation delays climax and also increases reported satisfaction, researchers said on Monday.

The drug, called dapoxetine, helped men delay their orgasms significantly and doubled the numbers of men and their female partners reporting "good" sexual satisfaction, they told a conference.

"Premature ejaculation is a really common problem, affecting between 10 and 30 percent of all men. Here is something for the first time that we have that works," said Dr. Jon Pryor, chairman of the Department of Urologic Surgery at the University of Minnesota, who led the study.

He said the drug worked quickly and with few side-effects.

"It gets in rapidly. It gets out rapidly. You can take it one to three hours before intercourse," Pryor said in a telephone interview.

The drug is being co-developed by Mountain View, California-based Alza Corp. and Johnson & Johnson Pharmaceutical Services LLC. Ortho Pharmaceutical will market the drug in the United States if it receives U.S. Food and Drug Administration approval. All three companies are units of Johnson & Johnson .

In a study presented to a meeting of the American Urological Association in San Antonio, Pryor said men who took dapoxetine at doses of either 30 mg or 60 mg had a three to four-fold increase in ejaculation time compared to men given a placebo.

The percentage of men rating control over ejaculation as "fair to very good" increased from 2.5 percent before getting the drug to 51.8 percent afterward for men who got the lower dose, to 58 percent of men given the higher dose.

Of the men who got the placebo, 3.5 percent reported fair to very good control before getting the dummy pill and 26.4 percent said so afterward.

INCREASES SEXUAL SATISFACTION

"The percentage of men rating sexual satisfaction as 'good to very good' almost doubled with dapoxetine 30 mg (20.2 percent to 38.7 percent) and 60 mg (22.3 percent to 46.5 percent)," the company said. Just under 25 percent of men who got the placebo reported good sexual satisfaction.

Only about 20 to 25 percent of the men's partners felt satisfied by sex before the men took the drug but this doubled to 47 percent after the men took the highest dose.

The trial was a phase III clinical trial of 2,614 men, designed to be the last test before seeking U.S. Food and Drug Administration approval.

It is a drug called a serotonin transporter inhibitor.

"We know that you need serotonin to ejaculate," Pryor said. But he said no one truly understood how ejaculation works, or precisely how the drug affects serotonin, an important message carrying chemical used by nerve cells.

The companies have worked hard to define just what premature ejaculation is in order to set parameters for testing the drug.

But they anticipate a good market.

The American Urological Association estimates that premature ejaculation affects anywhere between 27 percent and 34 percent of men across all age ranges. Erectile dysfunction, the condition that made Pfizer's impotence drug Viagra into a blockbuster, affects an estimate 10 percent to 12 percent of men.

Researchers working on the drug reported last month that they could define premature ejaculation. They said a man with the condition took 1.8 minutes to ejaculate after beginning intercourse compared to 7.3 minutes for most men.

They call this Intravaginal Ejaculatory Latency Time and is timed by giving the man or his sexual partner a stopwatch.

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Originally posted by E-Dog Night

I don't need this drug.

Me neither!

Why should I pay money for a pill when thinking about baseball accomplishes the same thing and it doesn't cost me a penny...uh....ummmm...aw...nevermind...forget I said anything. :rolleyes:

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Oh, BTW I'm glad I'm not Turkish.:)

Watch the clock, darling – Brits last longest at sex

May 22, 2005

Ben Dowell

A SCIENTIFIC study to be published this week will suggest that British men are world leaders at sex, at least when they are measured against the clock.

But that is not saying much considering that most men in other countries were at best five-minute wonders.

After equipping hundreds of couples in various countries with stopwatches, researchers have for the first time amassed accurate data on the length of time that people spend having sex.

Across all the countries studied, the average time for actual lovemaking was 5.4 minutes. Around that figure, however, the researchers found considerable variations related to age and nationality.

While British men took on average 7.6 minutes, the typical American took 7 minutes, while the Spanish lasted 5.8 minutes and the Dutch 5.1 minutes.

The Turks produced the biggest surprise: on average they spend just 3.7 minutes at it.

In all the countries studied there was no significant difference in the timings whether the men were using condoms or not.

In the research, to be published in the Journal of Sexual Medicine, British and Dutch scientists studied 500 couples aged over 18 in the five countries.

“Sexual events were stopwatch-timed over a four-week period and recorded,” says Dr Marcel Waldinger, a leading neuro-psychiatrist based at Utrecht University who led the research.

The findings also revealed how the time from start to finish of sex decreased with age, from an average of 6.5 minutes for men aged 18-30 to 4.3 minutes for those over 51.

The researchers say the findings indicate that male sexual functioning varies significantly between healthy individuals, and there is no easy definition of what should be classified as average sexual performance or premature ejaculation.

“The wide range among normal men points to a physical rather than a psychological cause for premature ejaculation,” said Waldinger.

“The results will help to lift the taboo over premature ejaculation because they show that men are indeed different from one another.”

Just why there are significant national differences is not clear and the researchers plan bigger studies and yet more research to find an explanation.

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Originally posted by SkinsHokieFan

How do you get to be a part of these studies?

Originally posted by China

Oh, BTW I'm glad I'm not Turkish.:)

Watch the clock, darling – Brits last longest at sex

The researchers say the findings indicate that male sexual functioning varies significantly between healthy individuals, and there is no easy definition of what should be classified as average sexual performance or premature ejaculation.

“The wide range among normal men points to a physical rather than a psychological cause for premature ejaculation,” said Waldinger.

“The results will help to lift the taboo over premature ejaculation because they show that men are indeed different from one another.”

Just why there are significant national differences is not clear and the researchers plan bigger studies and yet more research to find an explanation.

...not sure how you become part of the "research team" SHF...but it appears they will be conducting more studies...

"Okay, Hon....get the stopwatch...we gotta time ourselves again tonight. If I can just get over the 3 minute mark I'll set a personal best"

:D

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He said the drug worked quickly and with few side-effects.

"It gets in rapidly. It gets out rapidly. You can take it one to three hours before intercourse," Pryor said in a telephone interview.

Finally, a drug I can identify with! :laugh:
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also increases reported satisfaction, researchers said on Monday.

Does it seem ridiculous to anyone else that they would need to spell this out? If the general consensus wasn't that lasting longer=better sex then why would this study ever have existed?

If premature ejaculators and their partners were totally happy with the situation, nobody would want to participate in the study; of course longer sex is going to increase satisfaction for both people! :doh:

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Originally posted by SkinsNut73

Why should I pay money for a pill when thinking about baseball accomplishes the same thing and it doesn't cost me a penny...uh....ummmm...aw...nevermind...forget I said anything. :rolleyes:

Math computations are much more effective...

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