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BT: The Invisible Mouse


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The Invisible Mouse

Several years ago, a colleague came to Japanese researcher Atsushi Miyawaki with a simple observation. While performing a Western blot experiment with gels, he noticed that the light scattering properties of the gels disappeared when submerged in a solution containing the common laboratory compound urea. So, Miyawaki wondered if a urea solution could also reduce the light scattering of tissues, which would allow biologists to peer deeper into an organism to observe its hidden physiology. And it did.

2011-12-20_001_170879b.jpg

Miyawaki and colleagues at Riken have developed a clearing reagent that can make tissue transparent without affecting fluorescent labeling techniques. Source: Nature Neuroscience

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