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BT: The Invisible Mouse


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The Invisible Mouse

Several years ago, a colleague came to Japanese researcher Atsushi Miyawaki with a simple observation. While performing a Western blot experiment with gels, he noticed that the light scattering properties of the gels disappeared when submerged in a solution containing the common laboratory compound urea. So, Miyawaki wondered if a urea solution could also reduce the light scattering of tissues, which would allow biologists to peer deeper into an organism to observe its hidden physiology. And it did.


Miyawaki and colleagues at Riken have developed a clearing reagent that can make tissue transparent without affecting fluorescent labeling techniques. Source: Nature Neuroscience

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